Human stem cell-derived cardiomyocytes integrate into the heart of monkeys with surgically-created congenital-like cardiac defect

To investigate the transplantation of human induced pluripotent stem cell-derived cardiac lineage-cells into the heart of rhesus macaques with a surgical model of right ventricular pressure overload. Overall design: We study gene expression profiling of hiPSCs reprogrammed from human fibroblast cells and hiPSCs stem cell-derived cardiomyocytes Comparative gene expression profiling analysis of bulk RNA-seq data for human induced pluripotent stem cell-derived cardiac lineage-cells