Expression data from human 3D skin models treated with synthetic pseudo-ceramide for medical containing steroid cream

Ceramides in the stratum corneum (SC) play an important role in the epidermal barrier function. We focused on these functions and developed a synthetic pseudo-ceramide for medical (SPCM)-containing steroid cream [SPCM (+)]. This cream forms films on the skin surface with multilamellar structures, like the human SC, and exerts anti-inflammatory effects through steroids. However, the preventive effects of this cream on disruption of skin barrier remain unclear. This study aimed to analyze the efficacy of SPCM (+) using human three-dimensional (3D) skin models. Overall design: In this data set, we included expression data from human 3D skin models treated with or without SPCM (+) under exposure to V8 protease derived from Staphylococcus aureus.