Most significant SNP associations with ventricular dysfunction after primary coronary artery bypass grafting with cardiopulmonary bypass in covariate adjusted meta-analyses.^*

MAF = minor allele frequency; SNP = single nucleotide polymorphism; VnD = ventricular dysfunction; *Cases and controls were from the CABG Genomics validation and replication studies and the Vanderbilt replication study. SNP data for these subjects were assessed by institution, with covariate adjustments made for age, preoperative left ventricular ejection fraction, and duration of cardiopulmonary bypass. Results were then combined using meta-analysis. 17 SNPs studied across the CABG Genomics validation study and the Vanderbilt and CABG Genomics replication studies were assessed. Meta-analysis results for all 17 SNPs are shown in Table S5. †Results for best genetic models in the genome-wide association study (additive, dominant, or recessive). ‡Odds ratios and P values derived using random effects meta-analysis. §P value for Cochran's Q statistic assessment of heterogeneity (P<0.05 would mean effect sizes between institutions are significantly different). The I2 heterogeneity indices equaled 0 for all three SNPs shown in the Table.