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Divergent clonal differentiation trajectories of T cell exhaustion. Divergent clonal differentiation trajectories of T cell exhaustion

NIAID Data Ecosystem2026-03-13 收录

T细胞耗竭

克隆分化

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA779919 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

应用场景：

创建时间：

2021-11-12

肿瘤免疫治疗

T细胞耗竭

VEGF-A drives TOX-dependent T cell exhaustion in anti–PD-1–resistant microsatellite stable colorectal cancers Overall design: Normal colon, MC38-OVA, Control siRNA transfected, TOX siRNA transfected C

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RNA-Seq analysis of P14 CD8+T cells in B16-GP tumors

肿瘤浸润T细胞

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CD8+ T cells play an important role in fighting against tumors. However, CD8+ T cells often become functionally impaired or “exhausted” in the tumor microenvironment. T cell exhaustion is a major hurd

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scRNA-seq, bulk RNA-seq, and ATAC-seq data from progenitor exhausted and terminally exhausted CD8+ T cells from tumors and chronic viral infection. scRNA-seq, bulk RNA-seq, and ATAC-seq data from progenitor exhausted and terminally exhausted CD8+ T cells from tumors and chronic viral infection

T细胞耗竭

免疫单细胞多组学

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

NIAID Data Ecosystem50

RNAseq of Wild Type and Prdm1/c-Maf cDKO CD8+ Tumor infiltrating lymphocytes isolated from B16F10 melanoma

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Expression of co-inhibitory receptors, such as CTLA-4 and PD-1, on effector T cells is a key mechanism for ensuring immune homeostasis. Dysregulated co-inhibitory receptor expression on CD4+ T cells p

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scRNA-seq of antigen-specific CD8+ T cells from tumor draining LN, TIL and PBMC of melanoma bearing mice

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T细胞耗竭

CD8+ T cell-mediated immune response plays a pivotal role in controlling tumor growth.However, within the tumor microenvironment (TME), prolonged antigen exposure, as well as immunosuppressive factors

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Divergent clonal differentiation trajectories of T cell exhaustion. Divergent clonal differentiation trajectories of T cell exhaustion

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