Dorsal root ganglion single-cell RNA-seq dataset of painful diabetic peripheral neuropathy rat, diabeitc rats, and health rats

Painful diabetic peripheral neuropathy (PDPN) is a common complication of diabetes mellitus (DM). As one of the most disturbing symptoms, mechanical allodynia (MA) in PDPN remains largely unexplored. This dataset contains single-cell RNA sequencing results from rat dorsal root ganglion (DRG). The goal of this experiment was to investigate the transcriptional changes of distinct cell types in the DRG along MA development. Diabetic rats were induced by injected streptozotocin (STZ) on Day 0. We grouped diabetic rats according to the 50% paw withdrawal threshold (PWT) on Day 28. Rats with PWT ≤ 8 g were selected into the PDPN group and rats with PWT ≥ 15g were selected into the DM group. Rats in normal group (N group) were injected vehicle on Day 0. This experiment contains 8 samples (4 PDPN, 2 DM and 2 N), each of which combined bilateral L5 DRG collected from one male rat.