adeno-associated virus 2 Genome sequencing and assembly. adeno-associated virus 2

In 2022, a cluster of severe childhood hepatitis was detected primarily in Europe and North America, leading to a global alert by the world health organization. An association with adeno-associated virus 2 (AAV2) in conjunction with human adenoviruses was found. Five percent of the cases progressed toacute liver failure, necessitating transplantation. The mechanism of disease that account for fulminant liver failure in these patients remains incompletely described. An upsurge of in total five cases of acute liver failure presented to the Dutch national referral center for pediatric liver transplantation in spring 2022. An in-depth molecular analyses into the mechanism of pediatric acute liver failure was performed, including metagenomics of the cases in the Netherlands. The (partial) AAV2 genomes of that were found in the explanted liver tissue and plasma samples will be published in this BioProject. Other sequencing data is available upon request given the ethical regulatory restrictions linked to the consent.