Confirmatory interaction analysis.

For each SNP pair, chromosome (CHR), RS number (RS), nucleotide types (NT) and gene information (GI) are shown. Based on combined samples or independent samples in CMAS, the interactive effect was examined using a ULR-NOMINAL analysis [model: logit{Prob(Y = YOH|I11, I12,I21,I22,I11×I21,I11×I22,I12×I21,I12×I22,IGender,ZAge)} = a0+a11×I11+a12×I12+a21×I21+a22×I22+b1×I11×I21+b2×I11×I22+b3×I12×I21+b4×I12×I22+c×IGender+d×ZAge] or a ULR-ORDINAL analysis [model: logit{Prob(Y = YOH|X1,X2,X1×X2,IGender,ZAge))} = a0+a1×X1+a2×X2+a3×X1×X2+c×IGender+d×ZAge], where Y is YOH status, Iij is an indicator of the three genotypes (j = 1, 2) of SNP i (i = 1, 2), IGender is an indicator of gender, ZAge is a covariate for age, and Xi denotes the number of reference alleles of SNP i (i = 1, 2). The exact p values (in −log10 scale) for the combined and independent samples are shown.