The timing of Mdm2la/la embryonic lethality and rescue by Trp53 deletion.

(A), Viable embryos at the indicated days post conception from inter-mating of Mdm2la/+ heterozygotes. (B), Live mouse counts from inter-mating of Mdm2la/+:p53R/+ heterozygotes. (C), Viable embryos at the indicated days post conception from inter-mating of Mdm2la/+:p53R/+ with Mdm2la/+:p53R/R mice. n = number of live embryos; (n) = number of dead/resorbed embryos; [n] = Expected Mendelian frequency. Note: p53R/R mouse numbers were underrepresented due to loss of viability of female embryos in mid-gestation reported previously.