Proteomic profiling of carotid atherosclerotic plaques and adjacent intact arterial segments

Although it is well known that the extracellular matrix composition significantly impacts the development of neointimal hyperplasia and atherosclerosis, the biochemical cues regulating the cell-ECM interactions within the neointima remain obscure. Here, we pairwise collected 14 atherosclerotic plaques excised during the carotid endarterectomy and 14 adjacent intact aortic segments and then interrogated their proteomic profile.