Gene Expression profiling of TgCRND8 brains at 18 months

Tau tangles and amyloid plaques are pathological hallmarkes of Alzheimer's disease (AD). To understand transcriptomics changes that occur in response to amyloid deposition, we have analyzed the brains of 18 month old mice from the TgCRND8 transgenic line which overexpresses APP and develop Thioflavin S-positive amyloid plaques beginning at 3 months of age. Overall design: Gene expression profiling of RNA from the forebrains of CRND8 transgenic (Tg) and non-transgenic (NTg) litter mates aged to 18 months.