Ncoa6

Enables several functions, including chromatin-protein adaptor activity; histone methyltransferase binding activity; and transcription coactivator activity. Acts upstream of or within brain development; circulatory system development; and positive regulation of DNA-templated transcription. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in breast cancer; colon cancer; and lung cancer. Orthologous to human NCOA6 (nuclear receptor coactivator 6). [provided by Alliance of Genome Resources, Nov 2024]

本数据集包含多个功能，包括染色质-蛋白质适配酶活性、组蛋白甲基转移酶结合活性以及转录共激活酶活性。其在脑部发育、循环系统发育以及DNA模板转录的正向调控等过程中发挥上游或内部作用。位于细胞核内，并构成转录调控复合体的一部分。在包括消化系统、中枢神经系统、早期胚胎、泌尿生殖系统和感觉器官在内的多个结构中表达。本研究旨在探讨扩张型心肌病。该基因的人类同源基因与乳腺癌、结肠癌和肺癌有关。与人类NCOA6（核受体共激活因子6）同源。[由基因组资源联盟提供，2024年11月]