Antiallergic Effects of Luteolin in IgE-Induced bone marrow-derived mast cells

This study investigated the antiallergic effects of Chamaecrista nomame extract (CN) and its isolated compound luteolin in a mouse model of ovalbumin (OVA)-induced asthma. We aimed to identify active substances within CN, elucidate their molecular signaling mechanisms, and assess their therapeutic potential for treating allergic asthma. Overall design: We screened 302 plant extracts for anti-degranulation activity, identifying CN as a promising candidate. In vitro assessments on RBL-2H3 cells and a mouse model of OVA-induced asthma were used to evaluate CN's effects. RNA sequencing and gene expression analysis in bone marrow-derived mast cells (BMMCs) were conducted to explore the molecular mechanisms. Luteolin was identified as a key bioactive component of CN.