Transcriptional effects of I-PpoI induced DNA double strand breaks in mouse lymphocytes

ChEBI2016-01-04 更新2026-07-12 收录

DNA损伤修复

淋巴细胞转录组

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Transcriptional effects of I-PpoI induced DNA double strand breaks in mouse lymphocytes

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2016-01-04

Effect of DNA break-induced transcriptional repression on genome stability. Homo sapiens

DNA损伤修复

染色质调控

Cohesin and the PBAF chromatin remodelling complex are required to repress transcription at sites of DNA double strand breaks. To investigate this and rule out known sister-chromatid dependent functio

NIAID Data Ecosystem60

DNA damage repair in barley following double-strand breaks and its dependence on ATR

DNA损伤修复

基因组稳定性

Maintaining genome integrity presents a particular challenge for plants due to their sedentary lifestyle, which disables direct avoidance of unfavorable external conditions. Additionally, plants’ meta

NIAID Data Ecosystem50

Specific UV-induced mutation spectrum in the p53 gene of skin tumors from DNA-repair-deficient xeroderma pigmentosum patients.

皮肤癌突变谱

DNA损伤修复

The UV component of sunlight is the major carcinogen involved in the etiology of skin cancers. We have studied the rare, hereditary syndrome xeroderma pigmentosum (XP), which is characterized by a ver

PubMed Central1993-11-15 更新40

Genome-wide Transcriptional Profiling Reveals MicroRNA-correlated Genes and Pathways in Human Lymphoblastoid Cell Lines

RNA调控网络

淋巴细胞转录组

Background: Expression level of many genes shows abundant natural variation in human populations. The variations in gene expression are believed to contribute to phenotypic differences. Emerging evide

NIAID Data Ecosystem50

Discovery of Isaindigotone Derivatives as Novel Bloom’s Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair

DNA损伤修复

抗癌药物设计

Homologous recombination repair (HRR), a crucial approach in DNA damage repair, is an attractive target in cancer therapy and drug design. The Bloom syndrome protein (BLM) is a 3′–5′ DNA helicase that

NIAID Data Ecosystem40

Transcriptional effects of I-PpoI induced DNA double strand breaks in mouse lymphocytes

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