Adjusted HRR and 95% CI of Incident Acute Coronary Events Associated with the COMT Genotype*, Plasma tHcy and Serum Folate and Gene-Homocysteine and Gene-Folate Interactions

Abbreviations: CI, confidence interval; COMT, catehol-O-methyltransferase; fol, serum folate concentration; HRR, hazard rate ratio; HRRi, hazard rate ratio for a multiplicative interaction; RERI, relative excess risk for interaction; tHcy, serum total homocysteine concentration.* COMT low activity Met158Met is ‘at-risk’ genotype for this study. The comparison group for the HRRs in the first three columns of the table is the same, i.e. subjects with lower plasma tHcy (COMT Met158Val or Val158Val genotype.†Model 1 is adjusted for age and examination years.‡Model 2 is adjusted for age, examination years, serum HDL and LDL cholesterol and triglycerides, systolic blood pressure and smoking