Semi-synthetic triterpenoids are antioxidant inflammation modulator (AIM) compounds that inhibit tumor cell growth and metastasis. Compounds in the AIM class bind to Keap1 and attenuate Nrf2 degradati

Figshare2016-01-15 更新50

Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1δ/ε

激酶抑制剂开发

肿瘤细胞生物学

Vaccinia-related kinase 1 (VRK1) and the δ and ε isoforms of casein kinase 1 (CK1) are linked to various disease-relevant pathways. However, the lack of tool compounds for these kinases has significan

NIAID Data Ecosystem40

Selective CDK9 inhibition by natural compound toyocamycin in cancer cell

CDK9靶向抑制

抗癌药物机制

Aberrant transcription in cancer cells is characterized by silencing of tumor suppressor genes (TSG) and activation of oncogenes. Transcriptomic changes are associated with epigenomic alterations such

NIAID Data Ecosystem80

Effect of FDX1 overexpression on gene expression in SUDHL-4 cells upon elesclomol stimulation. Effect of FDX1 overexpression on gene expression in SUDHL-4 cells upon elesclomol stimulation

基因功能验证

抗癌药物机制

To investigate the function FDX1 in the regulation of elesclomol (ES)-induced cell death, we established SUDHL-4 cell lines in which the full-length coding sequence of FDX1 was overexpressed (FDX1-OE)

NIAID Data Ecosystem40

Table S1 from DNA Replication Stress Induced by Trifluridine Determines Tumor Cell Fate According to p53 Status

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