Vonoprazan pharmacokinetics and effects on gastric pH following administration to fed and fasted horses

This dataset supports research characterizing the pharmacokinetics of
vonoprazan and investigating its effects on gastric pH in horses. The data
set includes pharmacokinetic parameters for individual horses generated
using non-compartmental pharmacokinetic analysis and the commercially
available software program Phoenix WinNonlin (Certara, Princeton, NJ).
Pharmacokinetic parameters generated from the pilot study (2
horses/group), assessing the effects of food on drug behavior (0.5 and 1
mg/kg oral doses), and a “full” study (n=6 horses) assessing the effects
of a 1 mg/kg oral dose administered with food are included. A second data
set includes gastric pH measurements as part of the “full” study (n=6
horses), both before and after vonoprazan administration (1 mg/kg oral
dose). Measurements were collected via an engineered probe that was used
to continuously measure intragastric pH for 12 hours before and 24 hours
after each treatment. Sandhill Scientific software (Milwaukee, WI, USA)
was used to determine the mean, maximum, and minimum pH. Calculations of
the %t>pH4 were calculated at different time intervals. While the
number of horses studied was limited, the results of the current study
provide data that will be helpful in the design of further studies to
assess the efficacy of vonoprazan in horses for the treatment of gastric
ulcers.