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Gene expression analysis of a MLL-rearranged leukaemia cell line, PER-485, treated with small molecule CCI-006.

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE115793
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A phenotypic cell-based high-throughput screen identified a novel small molecule, CCI-006 with selective cytotoxic activity against MLL-rearranged leukaemia cell lines. The aim of this experiment was to identify the mechanism of action of CCI-006 by investigating the gene expression changes induced in a MLL-rearranged leukaemia cell line following a short incubation with the compound. RNA was isolated from PER-485 cells treated with 5 μM CCI-006 or DMSO for 3 hours
创建时间:
2019-10-01
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