Effect of Vatinoxan on dexmedetomidine preconditioning on experimental ischemia-reperfusion injury in the equine small intestine

Pharmacological preconditioning with dexmedetomidine has been shown to ameliorate intestinal ischaemia reperfusion injury in different species including horses. However, it remains unknown if this effect is related to alpha2-adrenoreceptor activity. Therefore, the aim of this study was to determine the effect of dexmedetomidine preconditioning with and without the administration of the peripheral alpha2-antagonist vatinoxan. This dataset reports the histological score and the apoptotic cell counts following ischaemia reperfusion injury with dexmedetomidine preconditioning with and without the peripheral alpha-2-agonist vatinoxan.