Mutation frequency at the major codons including antiviral resistance and SVR-related codons in the sequenced NS5B region.

a. ‘Diverse’ indicates the mutation type of the coexistence with the wild type in a quasispecies distribution of a subject. Otherwise, ‘Conserved’ indicates the presence of only mutation types alone without the wild type in a quasispecies distribution of a subject.
b. C316/Q464 and N316/E464 were found in an exclusive manner. All the 33 subclones with the C316/Q464 type were found in patients with advanced liver disease, but not in Cs.