Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy
收藏NIAID Data Ecosystem2026-03-13 收录
官方服务：
资源简介：
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
应用场景：
创建时间：
2022-05-05
相关数据集
Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems
Missorting of MAPT/Tau represents one of the early signs of neurodegeneration in Alzheimer disease. The triggers for this are still a matter of debate. Here we investigated the sorting mechanisms of e
NIAID Data Ecosystem70
Transcriptomic changes upon the formation of a functional "on demand" degradation network in microglia I. Transcriptomic changes upon the formation of a functional "on demand" degradation network in microglia I
We report the exchange of alpha-synuclein aggregates from one cell to another and examined transcriptomic changes following protein exchange. By obtaining 12,461 genes from isolated RNA samples, we pe
NIAID Data Ecosystem40
RNA changes in hippocampus of transgenic murine model of tauopathy (rTg4510 mice) compared to controls at asymptomatic stage (2 months) of neurodegeneration as determined by mRNA deep sequencing.
The overall goal of the project is to assess the mRNA alterations in tauopathy conditions that occur at the presymptomatic stage of neurodegeneration. The animal model selected for this study is a wel
NIAID Data Ecosystem30
Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration
We used mRNA-seq analysis to explore the transcriptional response induced in BV-2 cells by stable overexpression Siglec-F and related human Siglec receptors compared to loss-of-function 2xY->F mutant
NIAID Data Ecosystem60
Virtual Screening and Testing of GSK-3 Kinase Inhibitors Using human SH-SY5Y Neuronal cells Expressing Tau Folding Reporter and Mouse Hippocampal Primary Neuron Culture Under Tau Cytotoxicity
Supplementary Figure S1. for IJMS
NIAID Data Ecosystem30
