Simulated PacBio HiFi and ONT data for ALPINE benchmark

This dataset contains four simulated long-read sequencing files used for benchmarking CRISPR gene editing outcome classification tools in the ALPINE manuscript. The simulated datasets represent CRISPR-Cas9 editing experiments at two T cell receptor loci (TRAC and TRBC) using two long-read sequencing platforms: simulated_hifi_trac.fastq.gz - PacBio HiFi simulation for TRAC locus simulated_hifi_trbc.fastq.gz - PacBio HiFi simulation for TRBC locus simulated_ont_trac.fastq.gz - Oxford Nanopore simulation for TRAC locus simulated_ont_trbc.fastq.gz - Oxford Nanopore simulation for TRBC locus Each dataset contains a balanced mixture of CRISPR editing outcomes including wild-type reads, small/large insertions and deletions, complex indels, and AAV vector integration events. Detailed methods and scripts for reproducing these simulated datasets are available at https://github.com/Maggi-Chen/ALPINE-manuscript-analysis.