Tcf-1 and HEB Cooperate to Establish the Epigenetic and Transcription Profile of CD4+CD8+ Thymocytes
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA451505
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资源简介：
Ablating either Tcf-1 or HEB in CD4+CD8+-thymocytes elicits similar developmental outcomes, including increased proliferation, decreased survival and reduced late Tcra rearrangements. We investigate how Tcf-1 and HEB co-regulate CD4+CD8+ thymocyte development by promoting chromatin accessibility, regulating nucleosome occupancy, and regulating gene expression at shared DNA binding-sites genome-wide.
创建时间：
2018-04-23
