Gene expression profiling of kidneys derived from Pkd1 conditional knock-out (KO) mice treated by salsalate, tolvaptan, and in combination

Computational identification of gene expression pathways or key regulatory factors in the Pkd1 KO kidneys treated by salsalate, tolvaptan, and in combination Using Affymetrix Mouse Gene 2.0 ST Arrays, the global gene profiling of 57 kidneys samples from wild type (n=10), KO (n=12), KO mice treated by salsalate (n=11), KO mice treated by tolvaptan (n=12), KO mice treated by salsalate plus tolvaptan (n=12) was performed