RNA sequeqncing data of Kat6a–/–, Kat6a+/– and Kat6a+/+ E12.5 dorsal telencephalon and of Kat6a+/– and Kat6a+/+ E16.5 cortical neurons

Mutation of one allele of the KAT6A gene encoding the histone acetyltransferase KAT6A (MOZ, MYST3) causes Arboleda-Tham-Syndrome (ARTHS), which is characterised by developmental delay, cognitive impairment and autism-like behaviours. We used mice to examine the effects of Kat6a mutations on gene expression in the develping cerebral cortex and cortical neurons. We examined the effects of homozygous and heterozygous loss of Kat6a on gene expression in the E12.5 dorsal telecencephalon, the embryonic precursor of the cerebral cortex, and the effects of heterozygous loss of Kat6a on gene expression in foetal cortical neurons. Overall design: N = 4 Kat6a–/– vs. 4 Kat6a+/+ E12.5 dorsal telencephalon; 4 Kat6a+/– vs. 4 Kat6a+/+ E12.5 dorsal telencephalon; 4 Kat6a+/– vs. 4 Kat6a+/+ E16.5 cortical neurons