Bulk RNA-seq analysis of Btk-deficient leukemia. Role of BTK in CLL pathogenesis
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https://www.ncbi.nlm.nih.gov/bioproject/PRJEB41313
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资源简介：
To characterize the functional consequences for CLL development, we generated a targeted Btk gene knockout in Eµ-TCL1-transgenic mice. Strikingly, Btk deletion did not prevent the development of leukemia in TCL1tg/wtBtk-/- mice. To understand the differential signaling events occurring in Btk-deficient versus Btk-proficient CLL cells, we investigated the transcriptomes of Btk-deficient versus wildtype CLL and performed bulk RNA sequencing on total splenocytes isolated from highly leukemic TCL1tg/wtBtkwt/wt (n=4) and TCL1tg/wtBtk-/- (n=4) mice.
创建时间：
2021-01-18
