Bertram1995_PancreaticBetaCell_CRAC

This a model from the article:

A role for calcium release-activated current (CRAC) in cholinergic modulation of
electrical activity in pancreatic beta-cells.

Bertram R, Smolen P, Sherman A, Mears D, Atwater I, Martin F, Soria B.
Biophys J1995 Jun;68(6):2323-32
7647236,

Abstract:

S. Bordin and colleagues have proposed that the depolarizing effects of
acetylcholine and other muscarinic agonists on pancreatic beta-cells are
mediated by a calcium release-activated current (CRAC). We support this
hypothesis with additional data, and present a theoretical model which accounts
for most known data on muscarinic effects. Additional phenomena, such as the
biphasic responses of beta-cells to changes in glucose concentration and the
depolarizing effects of the sarco-endoplasmic reticulum calcium ATPase pump
poison thapsigargin, are also accounted for by our model. The ability of this
single hypothesis, that CRAC is present in beta-cells, to explain so many
phenomena motivates a more complete characterization of this current.

This model was taken from the
CellML repository and automatically converted to SBML.

The original model was:

Bertram R, Smolen P, Sherman A, Mears D, Atwater I, Martin F, Soria B. (1995) - version=1.0

The original CellML model was created by:

Catherine Lloyd

[e-mail]

The University of Auckland

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