Application of Quality by Design Principles for the Definition of a Robust Crystallization Process for Casopitant Mesylate

GlaxoSmithKline (GSK) has identified casopitant as a potent NK1 antagonist. It was selected for its potential activities on a number of therapeutic targets such as inflammatory bowel disease, overacti

NIAID Data Ecosystem60

Computer-aided solvent mixture design for the crystallisation and isolation of mefenamic acid

The files contain the MINLP formulations presented in this publication. The MINLP problems are implemented and solved in GAMS version 28.2.0, using SBB, a local branch-&-bound MINLP solver.

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Self-Sorting Molecular Clips

We report the synthesis and characterization of 12 C-shaped methylene-bridged glycoluril dimers (1−12) bearing H-bonding groups on their aromatic rings. Compounds 1, 2, (±)-4a, (±)-5, (±)-7, and 8 for

NIAID Data Ecosystem30