In this project, we developed a novel antimicrobial peptide with antibacterial and antibiofilm properties. This peptide was tested for its bactericidal activity against intestinal pathogens. We could show that the human defensin fragment could reduced acute intestinal Salmonella and established Citrobacter infection, with minimal-side-effect on the gut microbiota. Human defensins are therefore promising targets to develop new treatment options.. Human defensin fragments to fight ESKAPE pathogens

In this project, we developed a novel antimicrobial peptide with antibacterial and antibiofilm properties. This peptide was tested for its bactericidal activity against intestinal pathogens. We could show that the human defensin fragment could reduced acute intestinal Salmonella and established Citrobacter infection, with minimal-side-effect on the gut microbiota. Human defensins are therefore promising targets to develop new treatment options.