Transplantation of exogenous mitochondria mitigates myocardial dysfunction after cardiac arrest

The incidence of post-cardiac arrest myocardial dysfunction (PAMD) is high, and there is currently no effective treatment available. This study aims to investigate the protective effects of exogenous mitochondrial transplantation. Exogenous mitochondrial transplantation can enhance myocardial function and improve the survival rate. Mechanistic studies suggest that mitochondrial transplantation can limit impairment in mitochondrial morphology, augment the activity of mitochondrial complexes II and IV, and raise ATP level. As well, mitochondrial therapy ameliorated oxidative stress imbalance, reduced myocardial injury, and thus improved PAMD after cardiopulmonary resuscitation (CPR).
Our study aims to investigate the protective effects of exogenous mitochondrial transplantation on the myocardium following cardiac arrest. We utilize a rat model of asphyxiation-induced cardiac arrest. Once the model is established, the rats are humanely euthanized for sample collection or survival analysis...., , , # Data from: Transplantation of exogenous mitochondria mitigates myocardial dysfunction after cardiac arrest

Dataset DOI: [10.5061/dryad.9cnp5hqwm ](10.5061/dryad.9cnp5hqwm)

## Description of the data

The following files are available:

Apoptosis: The level of the apoptosis in rat myocardium was measured as described in the Methods section: Flow Cytometry. (file format: fcs; file name: Apoptosis)

mPTP: The level of the mitochondrial permeability transition pore (mPTP) in rat myocardium was measured as described in the Methods section: Mitochondrial Swelling Assay. (file format: fcs; file name: *mPTP*).

ROS: The level of mitochondrial reactive oxygen species (ROS) in rat myocardium was measured as described in the Methods section: Determination of ROS. (file format: fcs; file name: *ROS*)

Data: The Excel spreadsheet containing the underlying data numerical va...,