Gene expression in rhesus monkey peripheral blood mononuclear cells (PBMCs) in response to long-term calorie restriction

The effect of a long-term calorie restricted diet was evaluated in PBMCs of rhesus monkeys For biopsy collection, the animals were given buprenorphine (0.01-0.03 mg/kg, IM) in the morning immediately preceding all biopsies and again that afternoon At the time of blood collection, control animals (24-27 years old) and CR animals (24-30 years old) had been subjected to CR for 16 years