Mechanism-GWAS-Causal-Graphs: Integrating Fine-mapping, Colocalization and Tissue Context into Causal Mechanism Graphs

Comprehensive data and analysis results for the Mechanism-GWAS-Causal-Graphs framework. Version 2.0.0 Updates: Added complete mechanism graph outputs for validated loci (SORT1, APOE, TCF7L2, and 50+ additional loci) Added benchmark gene datasets (Tier 1 gold standard, Tier 2 drug targets) Added cross-study replication results from GTEx to eQTL Catalogue Added calibration metrics and reliability diagram data Added comprehensive locus summary table with all analyzed loci Contents: data/processed/mechanism_graphs/ - JSON files with causal mechanism paths data/processed/benchmark/ - Gold standard gene lists with OMIM validation data/processed/replication/ - Cross-study eQTL replication results data/processed/calibration/ - Model calibration metrics (ECE, Brier, AUPRC) data/processed/locus_summary.tsv - Summary of all 52 analyzed loci This dataset supports the manuscript submitted to Nature Genetics.