Expression data from junctional zone of placenta in Brown Norway and Holtzman-Sprague Dawley rat strains at gestation day 18.5

Placentation differs in the BN rat strain when compared to HSD and DSS rat strains. Intrauterine trophoblast invasion is shallow and the junctional zone is underdeveloped in the BN rat. These structural differences are striking but their quantification is not conducive to high throughput analyses. In the rat, the junctional zone can be readily dissected and is more homogenous than other components of the placentation site. HSD and BN rat gestation day 18.5 junctional zone gene expression profiles were determined using DNA microarray analysis to identity placenta-associate quantitate traits.与HSD、DSS大鼠品系相比，BN大鼠品系的胎盘发生（placentation）存在显著差异。BN大鼠的子宫内滋养层侵袭较浅，且胎盘交界区（junctional zone）发育不全。此类结构差异虽十分明显，但难以通过高通量分析手段实现量化。在大鼠模型中，胎盘交界区易于解剖分离，且相较于胎盘着床位点的其他组分，其均一性更佳。本研究采用DNA微阵列分析（DNA microarray analysis），对妊娠第18.5天的HSD与BN大鼠胎盘交界区的基因表达谱进行了测定，以鉴定胎盘相关量化性状。