Whole Transcriptome Sequencing of Different Renal Function Groups in Children with Congenital Hydronephrosis

Hydronephrosis is a common symptom of congenital obstructive nephropathy that has an incidence rate of approximately 0.9%–7.7%. It is one of the most common congenital defects in prenatal diagnosis. Approximately 20%–30% of cases display clinical symptoms after birth and the outcomes of end-stage diseases are renal fibrosis and reduced renal function.Some children with hydronephrosis have heavy hydronephrosis but normal renal function, and some children with hydronephrosis have heavy hydronephrosis and decreased renal function. Therefore, we performed a whole transcriptome sequencing to find key regulators of renal function decline.The functionality of circRNA has been gradually discovered, and it mainly acts as a miRNA sponge to regulate gene expression in the regulation of neurological diseases, cardiovascular diseases, and various types of cancers [13,14,15]. However, very few studies on the role of circRNA in obstructive nephropathy have been reported.