Effect of chromosome 14 substitution on intrinsic exercise capacity in mice: R/qtl linkage analysis and phenotype data

B6A_CSS_F2.csv:File contains data formatted for use in R/qtl for linkage analysis. The first row contains the phenotype and SNP marker names. In the second row, chromosome numbers are indicated in the genotype columns. These cells are blank in the phenotype columns. The third row contains the position in centiMorgans of the SNP markers. These cells are blank in the phenotype columns. ID, mouse ID number; Strain, mouse strain; pgm, paternal grandparent; body mass, body mass in g at testing; time, exercise time in min; distance, distance run in meters; work, work performed during exercise test in kg•m; tbw, terminal body weight (g); heart, heart weight (mg); hwbw, heart weight to body weight ratio (mg/g); gastroc, gastrocnemius muscle mass (mg); rgbw, gastrocnemius weight to body weight ratio (mg/g); soleus, soleus muscle weight (mg); rsbw, soleus muscle weight to body weight ratio (mg/g); plantaris, plantaris muscle weight; rpbw, plantaris muscle weight to body weight ratio (mg/g); sex, female = 0, male = 1; SNPs used for genotyping, rs47601255, rs3719262, rs3696080, rs3697794, rs3660830, rs3023675, s3706792, rs3676913, rs3684516, rs30501790, rs3715673, rs3685710. Genotypes are indicated by AA for homozygous A/J, BB for homozygous B6, and AB for heterozygous. Body mass, time, distance, and work phenotypes are the mean values of two trials. Data were used to generate Figures 3 and 4 and Table 3 in the main article.
F2_data.csv: Phenotype data for CSS F2 mice used to generate Figure 2 and Tables 2 and 3 in the main article. ID, mouse ID number; SEX, female = 0, male = 1; BW1, body mass in g at test 1; BW2, body mass in g at test 2; BW_mean, average body mass of test 1 and 2; Time1, exercise time in min during test 1; Time2, exercise time in min during test 2; Time_mean, average time of tests 1 and 2; Distance1, distance run in m during test 1; Distance2, distance run in m during test 2; Distance_mean, average distance run during tests 1 and 2; Work1, work performed in kg•m during test 1; Work2, work performed in kg•m during test 2; Work_mean, average work performed during tests 1 and 2; HEART (mg), heart weight (mg); H/BM, heart weight to body weight ratio (mg/g); RG (mg), gastrocnemius muscle mass (mg); RG/BM, gastrocnemius weight to body weight ratio (mg/g); RS (mg), soleus muscle weight (mg); RS/BM, soleus muscle weight to body weight ratio (mg/g); RP (mg), plantaris muscle weight; RP/BM, plantaris muscle weight to body weight ratio (mg/g).
CSS_data.csv:Phenotype data for inbred male and female A/J, C57BL/6J, and B6.A14 mice. Data were used to generate Figure 1 and Table 1 in the main article. ID, mouse ID number; Strain, mouse strain; SEX, female = 0, male = 1; BW1, body mass in g at test 1; BW2, body mass in g at test 2; BW_mean, average body mass of test 1 and 2; Time1, exercise time in min during test 1; Time2, exercise time in min during test 2; Time_mean, average time of tests 1 and 2; Distance1, distance run in m during test 1; Distance2, distance run in m during test 2; Distance_mean, average distance run during tests 1 and 2; Work1, work performed in kg•m during test 1; Work2, work performed in kg•m during test 2; Work_mean, average work performed during tests 1 and 2; HEART (mg), heart weight (mg); H/BM, heart weight to body weight ratio (mg/g); RG (mg), gastrocnemius muscle mass (mg); RG/BM, gastrocnemius weight to body weight ratio (mg/g); RS (mg), soleus muscle weight (mg); RS/BM, soleus muscle weight to body weight ratio (mg/g); RP (mg), plantaris muscle weight; RP/BM, plantaris muscle weight to body weight ratio (mg/g).

B6A_CSS_F2.csv：文件包含为R/qtl软件进行连锁分析而格式化的数据。首行包含表型及SNP标记名称。第二行中，基因型列指示染色体编号，而表型列中的相应单元格为空。第三行包含SNP标记的摩尔根位置，表型列中的单元格同样为空。ID字段表示小鼠ID编号；Strain字段表示小鼠品系；pgm字段表示父系外祖父母；body mass字段表示测试时的体重（单位为克）；time字段表示运动时间（单位为分钟）；distance字段表示跑过的距离（单位为米）；work字段表示运动测试期间完成的工作量（单位为千克·米）；tbw字段表示终身体重（单位为克）；heart字段表示心脏重量（单位为毫克）；hwbw字段表示心脏重量与体重的比率（单位为毫克/克）；gastroc字段表示腓肠肌质量（单位为毫克）；rgbw字段表示腓肠肌重量与体重的比率（单位为毫克/克）；soleus字段表示比目鱼肌重量（单位为毫克）；rsbw字段表示比目鱼肌重量与体重的比率（单位为毫克/克）；plantaris字段表示趾长伸肌重量；rpbw字段表示趾长伸肌重量与体重的比率（单位为毫克/克）；sex字段表示性别，女性为0，男性为1；用于基因分型的SNPs包括rs47601255、rs3719262、rs3696080、rs3697794、rs3660830、rs3023675、s3706792、rs3676913、rs3684516、rs30501790、rs3715673、rs3685710。基因型以AA表示纯合子A/J，BB表示纯合子B6，AB表示杂合子。体重、时间、距离和工作表型为两次试验的平均值。数据用于生成主文章中的图3和图4以及表3。

F2_data.csv：CSS F2小鼠的表型数据，用于生成主文章中的图2以及表2和表3。ID字段表示小鼠ID编号；SEX字段表示性别，女性为0，男性为1；BW1字段表示测试1时的体重（单位为克）；BW2字段表示测试2时的体重（单位为克）；BW_mean字段表示测试1和2的平均体重；Time1字段表示测试1时的运动时间（单位为分钟）；Time2字段表示测试2时的运动时间（单位为分钟）；Time_mean字段表示测试1和2的平均时间；Distance1字段表示测试1时跑过的距离（单位为米）；Distance2字段表示测试2时跑过的距离（单位为米）；Distance_mean字段表示测试1和2的平均距离；Work1字段表示测试1时完成的工作量（单位为千克·米）；Work2字段表示测试2时完成的工作量（单位为千克·米）；Work_mean字段表示测试1和2的平均工作量；HEART字段表示心脏重量（单位为毫克）；H/BM字段表示心脏重量与体重的比率（单位为毫克/克）；RG字段表示腓肠肌质量（单位为毫克）；RG/BM字段表示腓肠肌重量与体重的比率（单位为毫克/克）；RS字段表示比目鱼肌重量（单位为毫克）；RS/BM字段表示比目鱼肌重量与体重的比率（单位为毫克/克）；RP字段表示趾长伸肌重量；RP/BM字段表示趾长伸肌重量与体重的比率（单位为毫克/克）。

CSS_data.csv：纯合子A/J、C57BL/6J和B6.A14小鼠的表型数据。数据用于生成主文章中的图1和表1。ID字段表示小鼠ID编号；Strain字段表示小鼠品系；SEX字段表示性别，女性为0，男性为1；BW1字段表示测试1时的体重（单位为克）；BW2字段表示测试2时的体重（单位为克）；BW_mean字段表示测试1和2的平均体重；Time1字段表示测试1时的运动时间（单位为分钟）；Time2字段表示测试2时的运动时间（单位为分钟）；Time_mean字段表示测试1和2的平均时间；Distance1字段表示测试1时跑过的距离（单位为米）；Distance2字段表示测试2时跑过的距离（单位为米）；Distance_mean字段表示测试1和2的平均距离；Work1字段表示测试1时完成的工作量（单位为千克·米）；Work2字段表示测试2时完成的工作量（单位为千克·米）；Work_mean字段表示测试1和2的平均工作量；HEART字段表示心脏重量（单位为毫克）；H/BM字段表示心脏重量与体重的比率（单位为毫克/克）；RG字段表示腓肠肌质量（单位为毫克）；RG/BM字段表示腓肠肌重量与体重的比率（单位为毫克/克）；RS字段表示比目鱼肌重量（单位为毫克）；RS/BM字段表示比目鱼肌重量与体重的比率（单位为毫克/克）；RP字段表示趾长伸肌重量；RP/BM字段表示趾长伸肌重量与体重的比率（单位为毫克/克）。