Transcriptomic analysis in Suv39h2-deficient brain during early neurodevelopment

To examine the molecular phenotype of Suv39h2-deficits during early neurodevelopment, transcriptome analysis in the E11.5 brain of Suv39h2-deficient mouse and wild-type littermates were performed. The Suv39h2 mutation was made using CRISPR/Cas9n-mediated genome editing为探究早期神经发育过程中Suv39h2缺陷的分子表型，本研究对Suv39h2缺陷型小鼠及其野生型同窝仔鼠的胚胎发育第11.5天（E11.5）脑组织开展了转录组分析。Suv39h2突变体通过CRISPR/Cas9n介导的基因组编辑技术构建。