Increased hepatic γ-OHPdG formation in mice fed a high fat diet during early fatty liver disease may be an initiating event for hepatocarcinogenesis through accumulation of mutations and this process
Liver carcinogenesis induced by DEN closely mimics the pathologies observed during human liver tumor initiation and progression. DEN treatment triggered c-Jun expression lasting up to at least 1 week
miR-122 is a highly-expressed liver microRNA that is activated perinatally and aids in regulating cholesterol metabolism and promoting terminal differentiation of hepatocytes. Disrupting expression o
Deposit includes raw data, intermediate and final analysis files used to build up supplementary figures and tables of the paper "MiR-21 Suppression Promotes Mouse Hepatocarcinogenesis" by Correia de S
Through the analysis of mouse liver tumours promoted by distinct routes (DEN exposure alone, DEN exposure plus non-genotoxic insult with phenobarbital and non-alcoholic fatty liver disease); we report