A perfect HSE4 element is specific to a clpB refolding regulon in S. cerevisiae.

Abbreviations: DP-I, dot plot motif I; IUPAC, International Union of Pure and Applied Chemistry; PWM, Position-Weighted Matrix; Ψ, pseudo-count correction.* Models 1–3 describe the genomic distributions of the clpB-specific HSE4 element using different descriptions. IUPAC DNA codes are used as needed except ‘N’ is represented by a dot (‘.’). Y = pYrimidine (C or T), and R = puRine (A or G).** Percentages refer to the fraction of all genomic loci matching the model signature that are known to be involved in prion homeostasis. All such loci are listed in bold in the penultimate column. Hits in CDS regions are not listed but are counted for the precision metric.A perfect HSE4 element is specific to a clpB refolding regulon in S. cerevisiae.