The Adipose Tissue Knowledge Portal Integrates Clinical and Experimental Data to Provide Biological Insights

White adipose tissue plays a pivotal role in energy storage and release, and disruptions in these processes, marked by transcriptional disturbances, are linked to cardiometabolic diseases. Consequently, many efforts have focused on understanding adipose tissue function through transcriptional analyses. However, the resulting data are scattered and lack a unified approach for exploration. To address this gap, we present the Adipose Tissue Knowledge Portal (ATportal; www.adiposetissue.org) where we have systematically collected, generated, re-analyzed, and integrated transcriptomic and proteomic data from diverse clinical cohorts, multiple adipose-residing cell types, and perturbation studies of human adipocytes. Using the ATportal, we identify genes associated with lipid turnover in clinical samples and test their function in a mini-depletion screen. Our data reveal that the tyrosine-kinase receptor TYRO3 acts as a positive regulator of hormone-stimulated lipolysis. Overall, our open-access framework allows integrative analyses and serves as a powerful discovery tool to uncover new aspects of adipose biology.