Expression data of circRNAs from the fetal rats with anorectal malformations

Anorectal malformations (ARMs) are among the most common congenital terminal digestive tract malformations. Circular RNAs (circRNAs), a novel type of endogenous non-coding RNAs, play roles in the development of the digestive system; however, their contributions to the pathogenesis of ARMs are not well-established. Many dysregulated circRNAs as the primary factor could play an important role in the development of anorectum. We used high-throughput sequencing to reveal the regulatory mechanism of gene expression underlying the development of anorectal malformations. These results provide original insight into the roles of circRNAs in ARMs and provide a valuable resource for further analyses of molecular mechanisms and signaling networks.肛门直肠畸形（Anorectal malformations, ARMs）是最常见的先天性终末消化道畸形之一。环状RNA（Circular RNAs, circRNAs）作为一类新型内源性非编码RNA，在消化系统发育过程中发挥调控作用；然而其在肛门直肠畸形发病机制中的贡献尚未得到充分阐明。诸多表达失调的环状RNA可作为核心调控因子，在肛管直肠发育进程中发挥关键作用。本研究采用高通量测序技术，揭示了肛门直肠畸形发育过程中基因表达的调控机制。本研究结果为阐明环状RNA在肛门直肠畸形中的作用提供了原创性见解，同时为后续解析分子机制与信号网络提供了宝贵的研究资源。