Memory or naive T cell origin of VZV gE-specific T cell clonotypes boosted by zoster vaccination.

Subjects were vaccinated with either the live attenuated zoster vaccine (n=5) or recombinant zoster vaccine (n=10). Peripheral blood mononuclear cells were obtained before vaccination (baseline), at peak response approximately one month after vaccination, and after 5 years. The TRB sequences for VZV gE-specific T cell clonotypes were identified from CD4 T cells that proliferated in response to overlapping peptides spanning the VZV gE protein. To assess if the vaccines recruited responses from existing memory or from naive T cells, VZV gE-specific clonotypes were cross-matched to naive and memory CD4 T cell subsets isolated from baseline PBMC.

This dataset contains the raw TRB sequences obtained using the Adaptive Biotechnologies Immunoseq platform for:

1) peak gE clonotypes

2) year 5 gE clonotypes

3) baseline memory CD4 T cell subsets

4) baseline naive CD4 T cell subsets.