QTLs for mammary tumorigenesis susceptibility in F2 (Dahl S x R)-intercross female rats.

QTL, quantitative trait locus; Mts, mammary tumorigenesis susceptibility; Chr, chromosome; %, the amount in % of total trait variance that would be explained by a QTL at these loci; Mbp, mega-base pair; LOD, logarithm of the odds score derived from the likelihood ratio statistic using a factor of 4.6; ↑, S-allele increases trait; ↓, S-allele decreases trait. Significance determined from 2000 permutations on data set: LOD 2.48 significant (S); LOD 1.30 suggestive (Sug).aOverlapping QTL detected in previous study: Mcs = mammary cancer susceptibility.bcandidate genes in rat-human syntenic regions; Prlh, prolactin hormone; Anpep, alanyl (membrane) aminopeptidase; Blm, Bloom syndrome homolog; Ece1, endothelin-converting enzyme-1; Smad2, SMAD family member 2.