The whole transcriptome expression profiling of human SKOV3 comparison between control and CtBP1 KD, ctbp2 KD and CTBP1/2 DKD.

To discover the regulatory role of CTBP1/2 in high grade serous ovarian cancer, The full cDNA was extracted from SKOV3 shRNA control and CtBP1/2 knockdown and then compared the expression profiles of them to discovery the key functions and pathways regulated by CtBP1/2.. There are four groups cells used for this expression profile comparison : control and CtBP1 KD, CtBP2 KD and CtBP1/2 DKD. The RNA was extracted from well cultured cells using TRIzol reagent, and whole transcriptome gene expression profiling were performed using an Affymetrix Human Gene 1.1 ST whole transcriptome microarray platform.