Profiling non-human primate exosomal RNA to understand the legacy of early life stress

Motivated to identify novel molecular pathways and processes that are enduringly perturbed as a consequence of childhood maltreatment, we isolated circulating extracellular vesicles (EVs) from plasma collected from adolescent rhesus macaques. RNA sequencing revealed that macaque plasma EVs contain RNA aligned to the microbiome. We performed total RNA sequencing of the content of extracellular vesicles purified from rhesus macaque plasma