The enduring effects of early-life HFHS exposure and microbiota-targeted interventions on blood metabolome in adult female and male mice

Blood metabolomics of 12-week-old female and male C57BL/6J mice that were exposed to either a control or an unhealthy high-fat/high-sugar (HFHS) diet during early-life, or early-life HFHS diet supplemented with a microbiota-targeted intervention (either a prebiotic combination (fructo-oligosaccharides and galacto-oligosaccharides), FOS+GOS) or a putative probiotic (B. longum APC1472)). The overall aim of the project is to investigate the potential of microbiota-targeted approaches, via prebiotic combination FOS+GOS or the putative probiotic B. longum APC147, to attenuate detrimental enduring effects of an early-life HFHS diet, as a model of western diet, on offspring’s feeding behavior in adulthood.