Supplementary Material for: Refractive surgery for older children and adults with accommodative esotropia: a systematic review

Introduction: Accommodative esotropia (AET) is characterized by an esodeviation of the eyes due to uncorrected hyperopia, deficient fusional divergence, or high accommodative convergence. Decreasing hyperopia would reduce accommodative convergence and strabismus. We sought to review the existing evidence regarding the outcomes of refractive surgery in patients with AET. Methods: A four-database search (Pubmed, ISI Web of Science, Cochrane, and Scopus) was performed from inception to March 2021 using the MeSH terms: ("Refractive Surgical Procedures" OR "Keratomileusis, Laser In Situ" OR "Photorefractive Keratectomy" OR "Lens Implantation, Intraocular") AND ("Esotropia" OR "Accommodative Esotropia" OR "Refractive Esotropia” OR "Accommodative Strabismus"). No meta-analysis was performed due to studies’ heterogeneity. Results: Twenty-eight studies including 22 case series enrolling 378 patients and 6 case reports enrolling 8 patients were selected among 185 original abstracts. In the case series, a total of 378 patients (726 eyes) were recruited with an age range of 8-52 years. All studies reported mean follow-up periods of at least 12 months. Photorefractive keratectomy was performed in 7 studies, laser-assisted in situ keratomileusis in 9 studies, laser-assisted sub-epithelial keratectomy was reported in 1 study and 3 studies implanted IOL lenses, including iris-fixated and collamer. Considering the adult patients with a preoperative corrected esodeviation ≤10PD (n=129), all but five (3.9%) presented orthophoria or ≤10PD after refractive surgery. All children but 4 (4.5%) ended up with an esodeviation ≤10PD after surgery with those exceptions being in the range of 11 to 15PD. Six case reports were included in this review, comprising a total of 8 patients (16 eyes) with an age range of 7 to 34 years and a follow-up range of 4 to 48 months.Six case reports were included in this review, comprising a total of 8 patients (16 eyes) with an age range of 7 to 34 years and a follow-up range of 4 to 48 months. Discussion/Conclusion: Evidence produced so far points out that refractive surgery may be an alternative for spectacle correction for adults with accommodative esotropia ≤10PD. There is not enough evidence to recommend its use for patients under 18 years. The safety and predictability of these procedures for this purpose remains unclear as the selection criteria used for these patients are much different than the usual indications and there are no studies with long-term follow-up.