Binding of GRB2:GAB1 to p-ERBB2:p-EGFR

GAB1 in complex with GRB2 is recruited to activated ERBB2:EGFR heterodimer through phosphorylated tyrosine residues that serve as docking sites for GRB2 (Jackson et al. 2004).

GAB1与GRB2形成的复合物被招募至激活状态的ERBB2:EGFR异源二聚体，其中磷酸化的酪氨酸残基作为GRB2的对接位点（Jackson 等人，2004年）。