Development and Application of a Transcriptomic Signature of Bioactivation in an Advanced In Vitro Liver Model to Reduce Drug-induced Liver Injury Risk Early in the Pharmaceutical Pipeline

Translation of NRF1/NRF2-mediated liver tissue biomarkers to an in vitro assay using an advanced micropatterned co-culture system (HEPATOPAC®) with primary hepatocytes from male Wistar-Hannover rats or humans核呼吸因子1/核因子E2相关因子2（NRF1/NRF2）介导的肝组织生物标志物向体外检测实验的转化：采用先进微图案共培养系统（HEPATOPAC®），该系统使用雄性Wistar-Hannover大鼠或人类的原代肝细胞