The list of genes we further investigated using qRT-PCR.

Student's t-test statistic was employed such that a deregulation in fold change between infected and control samples showed at least a p-value≤0.1. The+or−represents a 1–2 fold change; 2.1–3.0 fold change is represented by++or−−while a ≥3.1 is annotated as +++. Blank spaces represent a lack of significant signal between infected and control samples. Relative microarray fold changes are highlighted in parenthesis. Pre-clinical time period spans up to and including 110 DPI while clinical represents 130 DPI and EP.