Subunit joining exposes nascent pre-40S rRNA for processing and quality control

NIAID Data Ecosystem2026-05-01 收录

核糖体生物合成

RNA质量控制

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资源简介：

Subunit joining exposes nascent pre-40S rRNA for processing and quality control

创建时间：

2024-03-20

mitoRibo-seq and RNA-seq of parental and MRM2 knockout HEK 293T Flp-In T-REx cells. mitoRibo-seq and RNA-seq of parental and MRM2 knockout HEK 293T Flp-In T-REx cells

核糖体生物合成

线粒体疾病机制

Methyltransferase MRM2 methylates the 2’-hydroxyl group of ribonucleotide U1369 of human 16S mt-rRNA. Mutations in MRM2 have been implicated in human mitochondrial-related disease. This study investig

NIAID Data Ecosystem110

The human RNA helicase DHX37 is required for release of the U3 snoRNP from pre-ribosomal particles

核糖体生物合成

RNA解旋酶功能调控

Ribosome synthesis is an essential cellular process, and perturbation of human ribosome production is linked to cancer and genetic diseases termed ribosomopathies. During their assembly, pre-ribosomal

Taylor & Francis Group2019-02-19 更新80

tRNAs marked with CCACCA are targeted for degradation

RNA质量控制

RNA降解机制

The CCA-adding enzyme adds CCA to the 3' ends of transfer RNAs (tRNAs), a critical step in tRNA biogenesis that generates the amino acid attachment site. We found that the CCA-adding enzyme plays a ke

NIAID Data Ecosystem80

The E3 SUMO ligase Mms21 controls ribosome biogenesis

核糖体生物合成

E3SUMO连接酶

The budding yeast E3 SUMO ligase Mms21, a component of the Smc5-6 complex, regulates sister chromatid cohesion, DNA replication, and DNA repair. We identify a role for Mms21 in ribosome biogenesis. Th

干细胞与再生医学数据中心2022-02-20 更新80

LINF_140021200

寄生虫基因功能分析

核糖体生物合成

mt-LAF21 | mitoribosomal LSU assembly factor 21 Leishmania infantum (strain JPCM5)

NIAID Data Ecosystem80