<b>Exploring the Therapeutic Potential of </b><b>Huoshan Dendrobium Zengye Jiedu Formula </b><b>in </b><b>Treating Radiation-Induced Oral Mucositis via Modulation of the EGFR/PI3K/AKT Signaling Pathway: An Integrated Approach Using Network Pharmacology, Molecular Docking, and Experimental Validation</b>

A total of 102 bioactive components and 379 potential targets for RIOM were identified. GO and KEGG enrichment analyses suggest that HDZJF exerts therapeutic effects on RIOM by modulating processes such as angiogenesis, inflammation, and apoptosis through pathways like PI3K-AKT. Molecular docking confirmed strong binding affinities between HDZJF components and key targets. In vivo, HDZJF reduced inflammation, promoted mucosal healing, improved body weight, and modulated protein expression related to EGFR/PI3K/AKT.